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Another AD study, focused on targeting CD38, showed that CD38 knockdown in APP Swe mutation-expressing transgenic mice enhanced NAD + levels and reduced A plaques in brain extracts, mirrored by some improvement of cognitive performance 270,274

10.23736/S2724-5276.22.06932-4 30 PhilippotG.HosseiniK.YakubA.MhajarY.HamidM.BuratovicS.et al (2022)

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In line with the concept that T cell activation and differentiation require metabolic adaptation, SLC1A5 couples TCR and CD28 signals to ultimately activate the mTORC1 pathway and enable the cell to undergo clonal expansion (105)