Wright RO, Baccarelli A
With further research on the mechanism of glutamine metabolism and the discovery of more related biomarkers, a more complete patient stratification system and a more personalized plan for cancer treatment can be established
Additionally, the interaction between NANOG, a gene associated with stem cells, and STAT3 increases MDR1 expression and the efflux of chemotherapeutic drugs, leading to chemoresistance development (70)
In lupus patients, it improved symptoms by blocking dysfunctional T-cells, which play a role in immune response (x, x, x)
however, hematological toxicities, such as thrombocytopenia, were observed (88)
(Source 1) Suboptimal and deficient glutathione levels are associated with aging and an increased risk for chronic diseases, including: Mitochondrial dysfunction Neurodegenerative disease, including Alzheimers and Parkinsons disease Cancer Chronic liver disease Metabolic disease, including diabetes and hypertension Cardiovascular disease Pulmonary Infertility Autoimmune diseases, including lupus and multiple sclerosis Mental health disorders Cystic fibrosis (Source 1, 2) A viral illness, including SARS-CoV-2, the virus that causes Covid-19, can also cause glutathione deficiency
