The high or moderate increase in ROS seems detrimental for myocardial cells, while its physiological level is necessary for normal cell signaling (123)
Chaudhari, N., Talwar, P., Parimisetty, A., dHellencourt, C
Ishizawa J, Kojima K, Hail N, Tabe Y, Andreeff M
The GH pulse it generates is pulsatile and physiological in character rather than the sustained elevation seen with exogenous hGH
It can activate the NLRP3 inflammasome and promote the release of inflammatory cytokines, thereby contributing to IR and pancreatic inflammation (42)
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