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Leucine did not stimulate growth and accretion in either stressed or unstressed Atlantic salmon

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Senescent mitochondria not only produce more ROS due to inefficient electron transport but also exhibit impaired iron-sulfur cluster biogenesis, leading to improper iron handling and accumulation within the mitochondria, thus creating a potent internal source of oxidative stress (106,107)

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Animal studies also help identify potential side effects and safety concerns, providing a comprehensive understanding of the peptide's efficacy and safety profile