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Several growth factors have been tested in vitro and most have been shown to successfully decrease cell apoptosis and/or to enhance chondrogenic matrix production, and/or to direct MSC differentiation towards a NP-like phenotype

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PMID 29669618

Evid Based Complement Altern Med 2016:8246171 Moncada S, Palmer RMJ, Higgs EA (1991) Nitric oxide: physiology and pharmacology