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Regarding selectivity and recovery, affinity chromatography methods are the most effective downstream processing techniques at the moment (Vollet Marson et al., 2020)
Following cardiac or cerebral ischemia, with rapid depletion of oxygen and nutrients, there are elevated levels of intracellular Ca 2+ and increased oxidative stress, changes that promote the opening of mPTP [55]
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This is a vital role because our cells need the energy to function effectively and oxidative stress has been linked to a whole number of diseases, including ALS, multiple sclerosis, Parkinsons disease, memory loss, depression, lung diseases, and as mentioned before, Alzheimers disease
