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Older adults might not absorb Vitamin B12 as well because their digestive system changes with age

Individuals with certain health conditions, such as Lebers disease (a rare inherited eye disease), should avoid B12 supplements as it can worsen the condition

Riboflavin is also essential for the metabolism of homocysteine, as a cofactor for methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR) (11)