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Unless otherwise indicated, cell viability was assessed 6d after plating, using the AQueousOne Solution Cell Proliferation Assay (Promega)

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Collagen and elastin, the proteins responsible for skin tone and firmness, require synthesis stimulation that the body may not provide at an adequate rate on its own, particularly when caloric intake is suppressed

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NaBPC157 (administered either in the ng or g/kg range, i.p.) significantly reduced the reactions in the writhing (inflammatory and non-inflammatory, prostaglandin-dependent and independent) and tail pinching tests