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Acknowledgements We acknowledge the contribution of Drs Abdullah Al-Tairar, Reem Al-Sabah, and Lemia Shaban in data collection in the original project (WF02/13)

Several risk factors contribute to the development of hemorrhoids: Chronic Constipation or Diarrhea: Straining during bowel movements can increase pressure on the veins

RNA sequencing and pathway enrichment analysis show FOXO4-DRI significantly downregulates extracellular matrix-receptor interaction pathways, including fibronectin (Fn1), tenascin C (Tnc), and thrombospondin 2 (Thbs2), all critical components of fibrotic tissue architecture

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Alcohol is a diuretic, meaning it increases urine output and depletes your body's water stores

ARID1A directly binds the Foxa2 promoter to regulate its transcription, essential for endometrial gland function