At first, the surface of the cartilage becomes worn, and with the continuation of the pathological process, deep cracks related to the shedding of cartilage fragments gradually forms, causing delamination and exposure of the calcified cartilage and bone below (Sandell, 2012) (Figure 1)
Biophys J , 114 (5), 10801090
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Peptide-Coordinated Cellular Activity Laboratory observations involving co-administration models propose that blends may exhibit broader signaling behavior compared to single-peptide presentations