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GSTM2 interacted with ASK1 and suppressed its phosphorylation and the activation of downstream p38-JNK signalling

Inflammation is the bodys way of protecting itself from illnesses or injuries

Hubert SM, Samollow PB, Lindstrom H, Mannervik B, Ing NH Conservation of glutathione transferase mRNA and protein sequences similar to human and horse alpha class GST A3-3 across dog, goat, and opossum species

Treatment options vary from topical drugs for minor conditions to systemic therapies and biologics for moderate-to-severe disease conditions

These may cause severe conditions including syncope, cardiac arrest, and sudden death especially when QTc is further extended