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Diagnosis can be rather complex as the symptoms can take years for it to surface

However, a dietary cause is a relatively uncommon reason

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Mechanistically, intra-articular AOD-9604 may stimulate synovial fibroblast proliferation or reduce inflammatory cytokine production in the synovial microenvironment, though direct effects on cartilage are unclear

[1, 2, 3, 4] Despite extensive research, the precise cellular and molecular mechanisms that drive the pathogenesis of those conditions are only partly understood, with a resulting variety of therapeutic approaches that depend on the symptoms, signs, and stage of the disease