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8 Clinical application prospects of DPP1 inhibitors 8.1 Bronchiectasis Bronchiectasis represents a chronic respiratory disease characterized by permanent and abnormal bronchial dilation, usually secondary to recurrent airway infections and inflammation ( Current clinical practice lacks specific therapies approved for treating bronchiectasis, with clinical management primarily relying on empirical treatment strategies including antibiotic use, airway secretion clearance techniques, and bronchodilator application