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Modified rotenone PD models using a low dose and chronic administration have shown promising outcomes with selective nigrostriatal neurodegeneration and positive aggregation of -synuclein cytoplasmic inclusions (Betarbet et al., 2003

NO modulates mitochondrial biogenesis also during myocytes differentiation by S-nitrosylation-mediated activation of the transcription factor CREB (cAMP response element-binding protein), which efficiently binds to the PGC-1a gene promoter region increasing its concentration and downstream signaling events [76]

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Puerarin protects against high-fat high-sucrose diet-induced non-alcoholic fatty liver disease by modulating PARP-1/PI3K/AKT signaling pathway and facilitating mitochondrial homeostasis

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