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Liao, Y., Smyth, G

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The accumulation of amyloid- (A) is a pathological hallmark of AD, with A being produced through the cleavage of amyloid precursor protein (APP) by -and -secretases, generating peptides of A of varying length (Murphy and LeVine, 2010)

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Gasoyan, H

This may lead to subsequent physiological abnormalities including gut dysbiosis and systemic inflammation, eventually resulting in a pathological clotting system, chronic endothelialitis, vasoconstriction, and hypoxia, as found in similar conditions such as heat stroke (183)