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SS, AP, TD, and HV: formal analysis

In mice without PXR, the expression of NF-B target genes is substantially increased in multiple tissues, and small bowel inflammation is significantly increased [1]

The Ruminococcaceae and Lachnospiraceae are major butyrate producing families, although some clusters of Clostridium are also important [136]

The authors proposed multiple potential mechanisms including interactions with opioid, GABAergic, and monoaminergic systems, establishing the conceptual framework for subsequent mechanistic research into DSIP's neurophysiological actions

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