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A drug can not generally have an oral bioavailability value higher than its value for f H , and oral bioavailability can equal f H only when all of the drug escapes from the GI tract and is able to enter the portal circulation (i.e

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In the groups not treated with cysteamine, no lesions were noted (laparatomy and gastrectomy only 24 hours or 48 hours post-surgical period) nor was lesion potentiation observed in cysteamine treated laparatomized animals

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Ohyama, M., Kobayashi, T., Sasaki, T., Shimizu, A