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Pregnant or breastfeeding women should avoid MOTS-c given the absence of safety data in these populations, as is standard for all investigational peptide therapies

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doi:10.1007/s00405-016-4222-z Holmes S, Padgham ND

PMID 11167669

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Although there is still much to be learned in autoimmune diseases, it is promising to target cGAS-STING signaling for treatments given the abnormal activation of cGAS-STING signaling by cfDNA ( With the deepening of research, the significance of cGAS-STING signaling in rheumatoid arthritis has been gradually recognized