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[DOI] [PubMed] [Google Scholar] 121.Subramanian V, Rothenberg A, Gomez C, Cohen AW, Garcia A, et al

Research-grade products may differ from the pharmaceutical material used in clinical trials

Patients love the ease of simply applying a patch and going about their day

However, hyperpigmentation often does not respond to topical treatments alone

Anything beyond that is diminishing returns and delayed recovery

The increased bioavailability of reactive oxygen species (ROS) (termed oxidative stress) due to excess ROS generation, decreased nitric oxide (NO) levels, and reduced antioxidant capacity in the cardiovascular, renal, and nervous systems are common features of these processes (4, 5)