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It isn't just about the supplement

In Figure 1A Dihexa delivered at 100 pmoles (n=8, p 0.05) (Figure 5A, C and E and Table 4)

doi: 10.1016/j.redox.2016.09.003

In white adipose tissue of obese, insulin-resistant and aged mammals, NNMT is dramatically upregulated and because it consumes both the universal methyl donor (SAM) and the NAD precursor (nicotinamide), its hyperactivity simultaneously depletes the cellular methylation reserve and the NAD-salvage pool [1,2]