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Indeed, there was only one investigation in which the presence of fatigue (for at least 3 months) constituted the main and necessary inclusion criterion

What they did: n 536 adults with obesity (BMI 30 to 45)

Statements Author contributions SS: Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing original draft, Writing review & editing

M., Van Eyk, J

Under a non-monotonic curve, an increase producing less effect is ambiguous: it cannot distinguish being below the peak from having passed it

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