"The adipose tissue (AT) expandability hypothesis explains that the individual capacity to appropriately store energy surplus as fat within the AT prevents the toxic deposition of lipids in other organs, such as the pancreas. Looping back to the role of the brain in obesity, I would move one level higher in the cascade of downstream effects - to the central regulation of hedonic appetite and the wiring of the reward system, overexpressed obesogenic genes within the CNS, and the role of ultra-processed food
Nat Rev Drug Discovery 20:309325 Narita Y, Arakawa Y, Yamasaki F, Nishikawa R, Aoki T, Kanamori M, Nagane M, Kumabe T, Hirose Y et al (2019) A randomized, double-blind, phase III trial of personalized peptide vaccination for recurrent glioblastoma
Specific symptoms documented included diarrhea, flatulence, nausea, and increased appetite
Much of the available safety information comes from animal studies, provider observations, and user-reported experiences
I've actually stopped drinking alcohol completely due to feeling like that
It has become a foundational component of many cellular optimization protocols