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Conditions include alcoholic liver disease, viral hepatitis, cirrhosis, and primary or metastatic liver cancer Renal dysfunction : Impaired kidney function reduces B12 elimination, causing accumulation even with normal intake Haematological conditions : Myeloproliferative neoplasms, chronic myeloid leukaemia, polycythaemia vera, and hypereosinophilic syndrome increase transcobalamin production, elevating total serum B12 Laboratory interference : Macro-B12 (immunoglobulin-bound B12) and assay interference can cause spuriously elevated results without true excess In clinical practice, unexplained hypercobalaminaemia should prompt investigation for underlying disease, particularly in patients without obvious supplementation history
A survey of c-MET expression and amplification in 287 patients with hepatocellular carcinoma
In senescent cells, FOXO4 sequesters p53 in the nucleus, preventing it from triggering apoptosis
Avoid leaving vials on countertops or in warm vehicles
Some might need injections every two weeks to keep B12 levels right
