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In REDEFINE 1 (NEJM 2025, n=3,417, 68 weeks), cagrilintide monotherapy at 2.4 mg produced 11.8% mean body-weight reduction versus 2.3% with placebo

Liposomal or intravenous formulations may improve absorption, but clinical evidence in liver health remains limited

Compounding allows the active drug to be delivered in a hypoallergenic base free of the offending excipient

These might be a better option for people with increased nutrient needs or those at a greater risk of deficiency, including individuals with medical conditions that affect absorption

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As of 2026, cagrilintide isnt available in the United States, and it isnt part of any FDA-approved medication