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Transfer of nanocarriers across the BBB and biological effects The main goals for BBB-targeted nanocarriers are at least three-fold, namely increase solubility, enhance brain penetration to reach better therapeutic efficiency, and minimize peripheral side-effects

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Stockwell BR, Angeli JPF, Bayir H, Bush AI, Conrad M, Dixon SJ, Fulda S, Gascn S, Hatzios SK, Kagan VE, Noel K