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Pre-clinical data in multiple cancer cell lines (including breast, ovarian, pancreatic, colon, non-small cell lung, prostate, thyroid, hepatocellular and oral squamous cell carcinomas and melanoma) have shown the potentiation by HDIs of the effects of topoisomerase I inhibitors (camptothecin, irinotecan, topotecan) topoisomerase II inhibitors (epirubicin, doxorubicin, etoposide, mitoxantrone) and other DNA-damaging agents (cisplatin, oxaliplatin, bleomycin)

Spiekermann GM, Finn PW, Ward ES, Dumont J, Dickinson BL, Blumberg RS, et al

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Diabetologia 47 , 20122021, doi: 10.1007/s00125-004-1570-9 (2004)

They play crucial roles in numerous biological processes, acting as messengers within the body to signal various functions such as tissue repair, immune response, and hormone regulation

However, such exceptionally high and industrially relevant riboflavin levels are usually not encountered amongst spontaneous riboflavin-producing lactobacilli 183