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MOTS-c works through mitochondrial and AMPK signaling rather than appetite pathways

No adverse effects, allergic reactions, or irritation have been reported at concentrations up to 3%

If neurological symptoms are present (such as paraesthesia, ataxia, cognitive changes, or visual disturbances), more intensive treatment is required

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In diet-induced obesity models, this inhibition has been observed to reduce white fat accumulation and promote lipolysis, effectively reprogramming metabolic pathways toward enhanced energy expenditure