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The toxins, enzymes and metabolites of bacteria (predominantly Gram-negative anaerobic) present in the dental plaque play a key role in the initiation of the inflammatory process, but the exact pathomechanism is far from being understood in detail (5-8)

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Without rigorous quality control, one batch of an herbal extract might be far less potent (or conversely, contain more of a toxic constituent) than another

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Integrating these biomarkers into clinical practice could revolutionize early detection and risk assessment, allowing for proactive and personalized management approaches