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A aggregation and tau hyperphosphorylation can disrupt the calcium balance in neurons, leading to mitochondrial calcium overload, increased reactive oxygen species production, reduced ATP generation, and ultimately, neuronal apoptosis or necrosis [76, 77]

Sci Rep 12(1):8042

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Manvir Singh: I think the Catalpa bo about Shamanism in Japan is a really great book, I think, um, the Fallen Sky by Davi Awa and Bruce [00:53:00] Alpert