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FIGURE 33 The time course of drug accumulation and elimination

Refined Sugars: Excessive consumption of refined sugars can lead to increased oxidative stress and inflammation, which may reduce the effectiveness of glutathione

Loss of mitochondrial membrane potential can increase the release of cytochrome c, one pathway that leads to neuronal apoptosis

Human clinical data is lighter but growing, and clinical use in sports medicine has been widespread

Microbiome-targeted interventions like probiotics and diet have shown potential to modulate immune activity and may reduce disease activity, though more robust clinical evidence is needed

A history of the roles of cytochrome P450 enzymes in the toxicity of drugs