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Visual assessment has been shown to be unreliable as a screening tool to detect significant neonatal hyperbilirubinemia

[DOI] [PubMed] [Google Scholar] 129.Nabekura J., Noguchi K., Witt M.R., Nielsen M., Akaike N

2.1.6 Topiramate Topiramate is an antiepileptic drug that acts through the inhibition of isoenzymes of carbonic anhydrase (CA)

The challenge has been most apparent this year in Cape Town, where residents face severe restrictions as the result of a once-in-384-year drought

Using multiple high-throughput proteomics assays in two independent cohorts of konzo-affected children compared to unrelated individuals (Discovery) or their unaffected sibling (Validation) respectively, we demonstrate that levels of the critical plasma-based antioxidant enzyme Glutathione Peroxidase 3 (GPx3) are significantly reduced in those affected

In addition, the isoprenyl group can react with cysteine thiol and bind to proteins, thus forming irreversible S -prenylation reactions such as farnesylation