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Aryl acetic acid conjugates 18 and 19 as dual cyclooxygenases-2 (COX-2)/tumor necrosis factor-alpha (TNF-) inhibitors In some cases, to develop a new series of COX-2 inhibitors with improved effects against TNF-, compounds with balanced inhibitory activity against both COX isozymes were preferred over selective COX-2 inhibitors

yet its neutralizing activity is considerably less than that of T[SH] 2