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KPV (Lys-Pro-Val) is an u03b1-MSH-derived tripeptide investigated for NF-u03baB inhibition and anti-inflammatory cytokine modulation, adding an inflammatory signaling dimension

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A three-year study of patients receiving regular Epithalon courses observed no adverse effects in the treatment group, with significantly reduced mortality compared to control groups

A phase I study of indoximod, another IDO inhibitor, in combination with docetaxel, an antimitotic chemotherapy drug, showed stable or partially stable disease conditions in more than 50% of patients [132]

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PMID: 20930042