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3b), the larger the ligand-binding pocket becomes (Fig

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Furthermore, USP2 is rhythmically expressed across multiple tissues and is also induced by starvation, suggesting it integrates circadian and metabolic signals (Yan et al., 2008

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Our findings raise the question of whether ATF4-mediated ISR is generally present in these TKI-insensitive CML cells and what causes the activation of ATF4 translation in these cells