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Endothelial dysfunction, characterized by impaired nitric oxide (NO) production and increased oxidative stress, is a hallmark of hypertension

In addition to GABAergic signaling, astrocytes play a fundamental role in maintaining glutamate homeostasis, which is essential for modulating tonic activation of N -methyl- D -aspartate receptors (NMDARs) [284, 306], typically composed of two GluN1 subunits and either two GluN2A or two GluN2B subunits [307]

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Complementary DNA was generated using the qScript cDNA SuperMix (Quanta, 95048)