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& Huffnagle, G

The damaged intestinal villi also lose their ability to produce Diamine Oxidase (DAO), the primary enzyme responsible for breaking down dietary histamine

If a person meets the diagnostic criteria for cEDS, genetic testing should be done to confirm the diagnosis

Evidence to date is primarily derived from preclinical and animal models, with emerging case series data

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First, while our findings remained largely unchanged after excluding participants with comorbid schizophrenia and intellectual disability, and no significant effects of comorbid ADHD or depression were observed on the neurometabolite measures examined, we cannot entirely rule out the potential influence of comorbidities on our results