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The clinical implication of our findings is to use TdGSH to prevent progressive loss of -cell mass in diabetic patients, who have more glycaemic variabilities because of the vicious metabolic memory obtained from the disease, and to block the development of diabetic complications

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The indirect positive effect of flavonoids is their ability to behave as mild prooxidants and boost the antioxidant system, substantiated by the activated synthesis of enzymes and endogenous low-molecular-weight antioxidants such as glutathione

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