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Ultimately, the convergence of metabolic, epigenetic, and immunological research around lactylation is poised to open new avenues for precision oncology, offering novel strategies to overcome drug resistance, enhance the efficacy of immunotherapies, and reprogram the tumor ecosystem for durable clinical benefit

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Nature 375 (6526):813 Ma M, Jiang W, Zhou R (2024) DAMPs and DAMP-sensing receptors in inflammation and diseases

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Interestingly, NTAPP induced expression of Wnt3a among the tested Wnt ligands

Low-protein plant-based diets and several anti-diabetic medications have been linked to beneficial microbiome effects (Lau et al., 2021)