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Alogliptin (1 and 3 mg/kg/d) treatment significantly attenuated mRNA expression of matrix metalloproteinase (MMP-2 & MMP-9) and improved ROS (reactive oxygen species) and aneurysm in walls of rat

The broader picture is that the next generation of obesity treatments involves multi-target approaches, whether through single molecules activating multiple receptors (tirzepatide, retatrutide, survodutide, mazdutide) or through combination therapies pairing separate compounds (CagriSema)

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(PubMed) Goodwin JS, Goodwin JM, Garry PJ

Proteome birthdating reveals age-selectivity of protein ubiquitination