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They are not recognized as generally regarded as safe (GRAS) substances for dietary supplement use

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Supplied in a sealed research-grade vial format

Choline is the major precursor of betaine, and it is used by the kidneys to maintain water balance and by the liver as a source of methyl-groups for methionine formation

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The restoration of biomechanical properties demonstrated in animal ligament models suggests potential for improved outcomes compared to rest and splinting alone