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A study revealing marked clonal expansion of cytotoxic CD4 + T cells in Japanese supercentenarians expressing canonical cytotoxic effector molecules and transcriptional programmes resembling those of CD8 T cells, indicative of adaptive immune remodelling in exceptional longevity

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10.1371/journal.pone.0046111 PLoS One 22 BottoR.CallaiN.CermelliA.CausaranoL.RaineroI

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