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Preclinical wound healing Animal wound-healing studies in rats, mice, rabbits, and pigs reported faster wound contraction, increased collagen, and improved angiogenesis with GHK-Cu, including systemic effects when GHK-Cu was injected at one site and improved healing at distant sites

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Levothyroxine treatment generates an abnormal uterine contractility patterns in an in vitro animalmodel

Senescent fibroblasts and endothelial cells, through the secretion of SASPparticularly PDGF-Apromote an increase in myofibroblast numbers at wound sites, which positively affects wound healing [141]

Important to note, both PLP and 5-methyltetrahydrofolate require riboflavin in their biosynthesis using the active forms of riboflavin, FMN, and FAD, respectively (89) (Figure 4)

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