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[iv] Finally, a number of additional factors may influence the design of first-in-human clinical trials, including the presence or absence of biomarkers, the suitability of the selected preclinical models, and the demographic characteristics of the study participants

Specifically, we focus on the biochemical and molecular mechanisms through which AST influences cellular processes, including oxidative stress reduction, modulation of neuroinflammation, and protection against neuronal damage

Zhang, Q., Wu, G., Richards, E., Jia, S