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It should be noted that GSH ester tends to be enriched inside cells due to its hydrophobic nature and esterase-catalyzed hydrolysis of GSH ester to GSH

Researchers found that, compared with healthy controls, the levels of trimethylamine oxide, glutamine, and lactic acid in the plasma of patients with depression were significantly increased, while the levels of phenylalanine, valine, alanine, glycine, leucine, citrate, choline, lipids, and glucose were significantly decreased

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This suggests that GLP-1R mice may serve as a model of correlated metabolic-functional connectivity changes in the brain