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Among them, GLUT1 (SLC2A1) is ubiquitously expressed and mediates basal glucose uptake in various tissues, including the intestine 17,18

2) Under conditions of sustained systemic inflammation (as seen in PEM), high levels of circulating cytokines may degrade tight junction proteins (e.g., claudin-5 and occludin), leading to BBB disruption and increased paracellular permeability

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Bolontrade, MF, Worth LL, Marini FC, Andreeff M , Kleinerman ES