Pregnant or breastfeeding women who suspect B12 deficiency should have their levels tested by their prenatal care provider, who can recommend the appropriate supplementation route and dosage
Ethics declarations Conflict of interest All the authors agree with the content of the article and declare no conflict of interest (personal, academic or financial) associated with this study
FIGURE 6 3.7 Effect of DXN and TIR on ROS and MDA concentrations in the rat brain The activity of mitochondrial complex I was compromised following DXN treatment, and this impairment was not ameliorated by the co-administration of TIR (Figure 7a)
Additionally, existing cryo-EM structures all locate the catalytically active strand break at the same location relative to the rest of the complex, at the top, opposite the XLF/XRCC4/Ku protein interaction framework that bridges the two ends (Fig
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However, a major drawback of these databases is the lack of chronological information