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Studies suggest that Pal-GHK may potentially possess anti-RCS properties, particularly against radicals like acrolein, malondialdehyde, and 4-hydroxynoneal, and thus reduce the risk of protein glycation of skin cell structures and ECM structures

Moreover, at moderate levels, ROS oxidatively modifies KEAP1, thereby activating the NRF2 pathway, which induces the transcription of antioxidant genes such as SOD2, GPX1, and HO-1, establishing a defense against oxidative stress in granulosa cells [236]

DOI: 10.1002/pmic.202100153

As a unique mitochondrial-derived peptide (MDP), MOTS-c is studied for its role in systemic metabolic regulation and cellular energy homeostasis

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