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Both exogenous and endogenous antioxidants can manipulate the ROS levels, by regulating gene expression and signaling pathways, and eventually maintain the oxidative balance and the integrity of cellular components (24, 121)

As expected, administration of BSO in the established high ACTL6A-expressing PDX tumors (cases 1 and 3) attenuated tumor progression

These cells achieve metabolic homeostasis by regulating the dynamics of nutrients present in the microenvironment, and the ability of cancer cells to utilize them to produce energy and to synthesize macromolecules

Note: No significant changes in bone turnover markers (osteocalcin and bone-specific alkaline phosphatase) were observed in studies (PMID: 10373343, PMID: 10828840)

6f and 7c) and increased HMGB-1 expression (Figs

Kimball, S