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High homocysteine levels, frequently associated with these mutations, can lead to adverse reproductive health outcomes

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10.1089/jmf.2019.4490 202 Ycel.KaratoprakG

however, the two spindles failed to align and come into close apposition to form a compound barrel-shaped structure, producing 2-cell embryos with one or two binucleated blastomeres, which provides a potential rationale for the multinucleated blastomere formation observed in human IVF-derived embryos 22