Lancet 390 (10113), 26272642
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No significant concerns in trials
Any important protocol modification such as changes to eligibility criteria, outcome analyses will be thoroughly communicated with DSMB members and will obtain amendment clearance from the institutional review board (IRB)
Summary Although SPECT provides an assessment of the BBB in vivo and, therefore, has the potential to be a valuable research tool, it continues to suffer from poorer photon detection efficiency (sensitivity) and lower spatial resolution than PET
It seems simple on the surface, but the answer has layers of nuance that can genuinely make or break the integrity of a research project